Bisquaternary ammonium compounds as potential tumor imaging agents
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چکیده
منابع مشابه
Bisquaternary ammonium compounds as potential tumor imaging agents.
Reports of rapid accumulation of 3Hor 14C-labelled hexamethonium in cartilaginous tissues after intravenous administration to rats and mice and of binding of hexamethonium to chondroitin sulfate in uitro prompted synthesis of radioiodinated analogs of hexamethonium. Tissue distribution studies in rats performed at 0.5 and 2 h after intravenous administration of “C-hexamethonium confirmed the pr...
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From the Department of Physiology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, Nijmegen, The Netherlands, the Max-Planck Institute for Biophysical Chemistry, Theoretical and Computational Biophysics Department, Am Fassberg, D-37077, Göttingen, Germany, and the Department of Chemistry, University of Edinburgh, Kings Buildings, West M...
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Prion diseases currently have no effective therapy. These illnesses affect both animal and human populations, and are characterized by the conformational change of a normal self protein PrP(C) (C for cellular) to a pathological and infectious conformer, PrP(Sc) (Sc for scrapie). We used a well characterized tissue culture model of prion infection, where mouse neuroblastoma cells (N2a) were infe...
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Vanadium is an element found in low concentrations in mammals, for which a function remains to be discovered. Over the past century, vanadium compounds have been suggested anecdotally as therapeutic agents for a variety of diseases. The discovery that vanadate inhibits various enzymes, in particular protein tyrosine phosphatases, and mimics many of the biological actions of insulin suggested a ...
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ژورنال
عنوان ژورنال: International Journal of Nuclear Medicine and Biology
سال: 1979
ISSN: 0047-0740
DOI: 10.1016/0047-0740(79)90030-5